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Outlook users get the error "Cannot open Microsoft Outlook. Outlook window cannot be opened It is impossible to open the set of folders. "The operation failed" usually means that outlook's data file cannot be opened. Outlook has all of the information stored in this file. Be sure to close any backup software that may be used to back up the data file before you begin the steps below. Outlook won't be able to access it if it is already in use.

Second, ensure that the file is not moved from its original location. the set of folders cannot be opened outlook 2016 Outlook can be interrupted by add-ins that prevent it from accessing the data files.

Method 1: Repair Corrupt System Files

Run Restore to scan for corrupt/missing files. You may also try the following methods.

Method 2: Reset Navigation Pane

This solution will allow us to reset Outlook's navigation pane settings. Close all other applications.

• Hold the Windows key and press R. Type in the run dialog.
• outlook.exe /resetnavpane
• Outlook should start fine if it does. Close Outlook and re-open it normally.
• Rename Outlook.xml to Outlook.xml.old if the Outlook.xml.old file doesn't open or it continues to refuse to open after you reset the navigation pane.
• To do this, hold the Windows Key and press R.
• Enter. Click on Outlook.xml and select rename. Add. old at the end.
• Open Outlook and check if Outlook works. If it doesn't

Method 3: Start Outlook in Safe Mode

1. Hold the Windows key and press R. Type outlook.exe/safe in the Run dialog and hit Enter.
2. When you log in, you will be asked to choose which profile you want. If you have only one profile, it will be used by default. Click OK. If it works in Safe Mode then it is most likely a corrupt or conflicting add-in. Open Outlook and disable all add-ins. If it still works, then you can enable each one until you reach the one that stops Outlook.
3. Click File -> Options-> Add-ins-> COM Addins-> Manage -> To disable add-ins
4. Check all items from Add-Ins Available List and click OK.
5. If that doesn't work, hold the Windows Key and press R. Type appwiz. CPL into the Windows Key and click OK.
6. Locate and remove the following programs.

ABBYY FineReader and Broadcom Send-to–Bluetooth Intel Send–to-Bluetooth King Soft’s Power Word.

Method 4: Repair Outlook Data File

Outlook stores data in data folders. These files can become corrupted. Outlook offers a tool called "ScanPST" to scan these files and repair them.

Method 5: Enabling cached swap mode

This method can only be used by exchange users.

1. Click Start to search for Control Panel. Type Mail in the search box at the top of the page. Click on the Mail icon in search results. Click Data Files in the Mail setup window. Click Settings, then select Your Account.
2. Check all boxes to enable cached exchange mode, download shared folders, and save public folder favorites. Close and test.

Method 6: Disable Lync at Startup

Lync, a business version for Skype, is available. It can often interfere with the Outlook application's most important features. In this step, Lync will be disabled at startup. We'll then open Outlook again. This is how it works:

Choose Task Manager from the list click on the "Startup” tab

1. Hold down the "Windows" and "X" keys simultaneously, then select "Task Manager", from the drop-down menu.
2. Click on the tab "Startup", and choose the Lync application from the drop-down menu.
3. To restart your computer, click on the "Disable” button.
4. Start Outlook without Lync, and then check to make sure the issue is still there.

Follow Method 3 until your ost/pst file is clear. Then create a new profile. Once done, import your ost/pst file back into Outlook. Set up Outlook to import your ost/pst file. If you have any missing contacts or messages, please make sure that Outlook is enabled before you start.